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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC4
All Species:
0.91
Human Site:
S671
Identified Species:
2
UniProt:
P56524
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56524
NP_006028.2
1084
119040
S671
K
H
Q
C
T
C
G
S
S
S
S
H
P
E
H
Chimpanzee
Pan troglodytes
XP_001151115
1072
118186
N656
K
H
Q
C
V
C
G
N
S
T
T
H
P
E
H
Rhesus Macaque
Macaca mulatta
XP_001099472
1009
112349
L568
Q
P
P
A
Q
A
P
L
V
T
G
L
G
A
L
Dog
Lupus familis
XP_849514
1222
133391
N791
K
H
Q
C
T
C
G
N
T
N
S
H
P
E
H
Cat
Felis silvestris
Mouse
Mus musculus
Q6NZM9
1076
118544
N668
K
H
Q
C
T
C
G
N
T
N
S
H
P
E
H
Rat
Rattus norvegicus
Q99P99
1077
118634
N669
K
H
Q
C
T
C
G
N
T
N
S
H
P
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510939
1082
119892
N674
K
H
Q
C
T
C
G
N
T
N
S
H
P
E
H
Chicken
Gallus gallus
P83038
1080
119449
N667
K
H
Q
C
T
C
G
N
T
N
S
H
P
E
H
Frog
Xenopus laevis
Q9YGY4
596
67288
S225
D
Q
S
S
P
P
P
S
G
T
S
P
T
Y
K
Zebra Danio
Brachydanio rerio
Q6PBI4
582
65098
P211
C
K
I
S
L
P
S
P
Q
D
Y
R
D
D
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17323
816
88964
I445
Q
S
I
W
S
K
L
I
E
H
G
H
V
Q
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.7
76.5
79.6
N.A.
93.6
93.4
N.A.
90.8
90.6
27.3
26.3
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
100
73.9
77.9
82.9
N.A.
96.3
96.1
N.A.
94.9
95
38.1
37.5
N.A.
N.A.
N.A.
46.4
N.A.
P-Site Identity:
100
73.3
0
80
N.A.
80
80
N.A.
80
80
13.3
0
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
93.3
13.3
100
N.A.
100
100
N.A.
100
100
20
6.6
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
10
0
0
0
0
0
0
0
10
0
% A
% Cys:
10
0
0
64
0
64
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
0
0
0
10
0
0
10
10
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
0
0
0
0
64
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
64
0
10
0
19
0
10
0
0
% G
% His:
0
64
0
0
0
0
0
0
0
10
0
73
0
0
64
% H
% Ile:
0
0
19
0
0
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
64
10
0
0
0
10
0
0
0
0
0
0
0
0
19
% K
% Leu:
0
0
0
0
10
0
10
10
0
0
0
10
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
55
0
46
0
0
0
0
0
% N
% Pro:
0
10
10
0
10
19
19
10
0
0
0
10
64
0
0
% P
% Gln:
19
10
64
0
10
0
0
0
10
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
0
10
10
19
10
0
10
19
19
10
64
0
0
0
0
% S
% Thr:
0
0
0
0
55
0
0
0
46
28
10
0
10
0
0
% T
% Val:
0
0
0
0
10
0
0
0
10
0
0
0
10
0
0
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _